منابع مشابه
p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis.
Glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids are important virulence factors of Mycobacterium tuberculosis. Although both types of molecules are thought to be derived from p-hydroxybenzoic acid, the origin of this putative biosynthetic precursor in mycobacteria remained to be established. We describe the characterization of a transposon...
متن کاملThe effect of sorbic acid and esters of p-hydroxybenzoic acid on the protonmotive force in Escherichia coli membrane vesicles.
The effect of three food preservatives, sorbic acid and methyl and butyl esters of p-hydroxybenzoic acid, on the protonmotive force in Escherichia coli membrane vesicles was investigated. Radioactive chemical probes were used to determine the two components of the protonmotive force: delta pH (pH difference) and delta psi (membrane potential). Both types of compound selectively eliminated delta...
متن کاملINHIBITION OF ESCHERICHIA COLI BY p-AMINOBENZOIC ACID AND ITS REVERSAL BY p-HYDROXYBENZOIC ACID
p-Aminobenzoic acid (PABA) exerts three metabolic effects on E. coli: it acts as a normal vitamin at low concentrations, as a source of another vitamin, p-hydroxybenzoic acid (POB), at moderate concentrations, and as a growth inhibitor at high concentrations (150 to 1600 microg./ml.). The inhibition is competitively reversed by POB in 1/100 the concentration of PABA. The inhibition is also reve...
متن کاملMetabolism of parabens (4-hydroxybenzoic acid esters) by hepatic esterases and UDP-glucuronosyltransferases in man.
Parabens (alkyl esters of 4-hydroxybenzoic acid) are widely used as preservatives in drugs, cosmetic products, and foodstuffs. Safety concerns have recently increased due to the potential health risks associated to exposure to large amounts of these substances. Biotransformation of parabens mainly includes hydrolysis of the ester bond and glucuronidation reactions. The hydrolysis and glucuronid...
متن کاملSynthesis of p-Hydroxybenzoic Acid and Salicylic Acid from Alkali Phenoxides in N,N-Dimethylformamide (1)
In a previous report, the synthesis of p-hydroxybenzoic acid and salicylic acid from alkali phenoxides and carbon dioxide in aprotic-polar solvents was reported. In the present study, the effects of reaction conditions on the yields and the rule of orientation under atmospheric pressure were examined in a typical aprotic-polar solvent, N,N-dimethylfomamide. Stabilities of the alkali salts of p-...
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ژورنال
عنوان ژورنال: Eisei kagaku
سال: 1980
ISSN: 0013-273X
DOI: 10.1248/jhs1956.26.326